The Glazers have finally run out of patience with David Moyes. Cherry picked by Sir Alex Ferguson and given a beefy six-year deal, Moyes has been given the boot after only 10 months.
Almost a year ago, the world's best coaches were falling over themselves to manage Manchester United - now each candidate to replace Moyes doesn't come without it's own degree of risk. Indeed, Juergen Klopp has already ruled himself out...
So who will replace Moyes at Old Trafford? Here’s Michael Da Silva's top five contenders…
Louis van Gaal (3.00 favourite)
Van Gaal is not only the most likely candidate but, crucially, the most available. He's already announced his decision to step down as Netherlands coach after the World Cup and is weighing up a few offers. Tottenham had proved the most tempting so far, but Van Gaal would surely leap at the chance to replace Moyes.
Ryan Giggs (7.00)
The Welsh wingman would be a popular choice, but a massive risk. His lack of football management experience – except for the last few months as a player/coach – would mean United are following up Moyes with another risky appointment. But having been at Old Trafford for so long, and honed his footballing prowess under Ferguson's successful regime of control, Giggs understands United better than most. No doubt a manager in the making, could Giggs's role as interim coach turn into something more permanent?
Roberto Martinez (15.00)
Could United poach another manager from Goodison? Martinez is building something special at Everton and is known for his loyalty, so it would take a lot for United to tempt him away after less than a year. But Martinez has further enhanced his reputation by introducing the attacking, exciting brand of football that United's tradition is built on.
Sir Alex Ferguson (20.00)
Could the unthinkable happen? Could Sir Alex come back to save United? The only thing that could convince the former boss to return is the nagging feeling that his legacy has been tarnished by his decision to appoint Moyes as his successor. Bringing back Fergie wouldn't be the craziest of choices, but at 72, he may feel he’s beyond the stress and the bother.
Diego Simeone (15.00)
Currently an outside bet and certainly not David Beckham's choice, but could quickly become a more realistic option if United don't move for Van Gaal. Simeone has had a phenomenal year in charge of Atletico Madrid and looks set to become the first coach in a decade to break Barcelona and Real Madrid's stranglehold of La Liga. But with prized asset Diego Costa looking set to jump ship in the summer, could Simone follow suit?
Who do you think will replace Moyes? Check our latest odds, which also includes Fabio Capello and former United defender Laurent Blanc.