Leeds United 2.30 The Draw 3.45 Southampton 2.90
This would've been a top of the table Championship clash this time last year. But 12 months on, and Nigel Adkins' Saints have joined the elite league, while Leeds, now presided over by the hospitable charms of Neil Warnock, are muddling along around mid table in the second tier.
That said, United have lost just once in their last seven games, a run that included a virtuoso display in dispatching a strong Everton side at Elland Road in the last round of this competition.
Saints, meanwhile, are second bottom of the big league having picked up just one point from a possible 12 of late.
With all of this in mind, the hosts are decent odds in front of their vociferous white army of support, especially as the visitors will likely rest some of their big guns.
Score prediction: Leeds 2-1 Southampton at 8.25
Bonus bet: H/T draw-F/T Leeds at 6.00.
Reading 3.90 The Draw 3.60 Arsenal 1.85
Jack Wilshere returned from a 15-month lay off in Arsenal's narrow win at home to QPR on Saturday, and the talented midfielder could now make his first away appearance of 2012 at the Madjeski Stadium. The Gunners were far from convincing in Saturday's 1-0 triumph against Mark Hughes' side, which is hardly surprising given their shaky form. They lost away at Norwich and at home to Schalke the previous week and will need their wits about them if they are to win through here.
Reading, meanwhile, have not won since the last round of this cup over a month ago, and their leaky defence has conceded 10 goals in their past five encounters. With Messrs Cazorla, Giroud and Podolski licking their lips in anticipation, this could prove a tough night for Brian McDermott's Royals against the 5.50 favourites to lift the trophy.
Rumours claiming the Arsenal team will be making the 50-mile trip to Berkshire on a private jet are as yet unconfirmed, but what we do know is that given the pressure Arsene Wenger is under to deliver any type of trophy to The Emirates, he's likely to ensure his charges are motivated and hungry in this live televised all Premier League clash.
Score prediction: Reading 0-3 Arsenal at 16.00
Bonus bet: Arsenal to be leading at half time at 2.45.
Sunderland 1.62 The Draw 3.75 Middlesbrough 5.25
It's been a topsy turvy season already for Sunderland. Martin O'Neill's troops have been solid enough in defence, but severely lacking creativity in the final third. As such, they've drawn a remarkable six of their eight Premier League games to date.
New signing Steven Fletcher has been prolific in patches, but the stats don't lie - the Black Cats have mustered just 12 shots at goal all season.
Near neighbours Middlesbrough are enjoying a halcyon period under the guidance of Tony Mowbray and are sitting pretty after four straight wins in The Championship. They also boast an exceptional away record this term and will not be daunted by the short trip up the North East coast.
Former 'Boro youth team products Adam Johnson and Lee Catermole will be keen to impress against their former club, and it's worth noting gaffer O'Neill has a sterling record in the League Cup having won it twice with Leicester City and reached the final with Aston Villa.
Expect a tight affair here, and with neither side willing to take risks, extra time could be a distinct possiblity.
Score prediction: Sunderland 1-1 Middlesbrough
Bonus bet: Draw at half time-draw at full time at 5.50.
Swindon Town 3.30 The Draw 3.20 Aston Villa 2.20
This intriguing tie has giant-killing written all over it. Not that Aston Villa have been particularly playing like giants recently.
Paul Lambert has struggled to find a rhythm as Villa boss so far. The Scot has based his team around a number of inexperienced young players, many of whom will not welcome a trip to the intimidating County Ground on a cold Tuesday night.
Paolo Di Canio has revived the fortunes of little old Swindon, who flirted with the Premier League during its infancy, but later went from bad to worse with a succession of relegations. The pushy Italian manager has sculpted a talented new side; a team comfortable in possesion, but solid in defence and powerful in attack all at the same time.
Currently stationed in and around the play-off places in League One, The Robins have already beaten three higher-ranked sides in the Capital One Cup this season, including a dramatic 4-3 extra time victory over Stoke City.
That result means they'll be fearless when stuttering Villa arrive. With this in mind, we could be in for another famous night down in Wiltshire.
Score prediction: Swindon 2-2 Aston Villa at 12.50
Bonus bet: Swindon to go through at 2.20.
Wigan Athletic 1.27 The Draw 5.50 Bradford City 10.00
The lowest ranked team left in the last 16 of the Capital One Cup, Bradford have got this far by virtue of the fact the draw has been kind to them so far. But this away trip to Wigan should spell the end of what has been a spirited journey for The Bantams.
City are enjoying a good season under the stewardship of Phil Parkinson and currently sit in the League Two play-off places thanks in no small part to the goalscoring feats of Bermudan striker Nahki Wells. The 22-year-old was plucked from the footballing scrapheap last year and has emerged as a diamond in the rough, notching 10 times already this term.
Wigan manager Roberto Martinez will be sure to inform his players this will be no cakewalk, but it is tough to see anything other than a home win here.
The Latics are coming off the back of a rousing win over West Ham on Saturday, and have won each of their previous Capital One Cup games by a 4-1 scoreline. A repeat of that can be backed at 17.00, but we're tipping an even more severe thrashing, as the hosts' Premier League class shines through.
Score prediction: Wigan Athletic 5-0 Bradford City
Bonus bet: Home team to score in both halves at 1.88.