Paris Saint-Germain go into this blockbuster Champions League clash in average form and, crucially, without talismanic striker Zlatan Ibrahimovic.
Ibrahimovic has scored five Ligue 1 goals already this season and his loss to injury provides Barca with a significant psychological boost before a ball has even been kicked.
The former Barca man has had several tests on a heel injury and will definitely miss out, a PSG statement confirmed on Monday night.
But a bigger worry for Paris is their distinctly average form going into tonight’s clash. They remain unbeaten in the league, but have drawn five of their last seven games in all competitions. It’s a run that should worry them going into a game against one of Europe’s form sides.
Barcelona, in contrast, have learned how to defend under Luis Enrique. So much so that they haven’t conceded a goal in a competitive game since May. Yes, May! That was Diego Godin’s strike for Atletico Madrid in La Liga, shortly before the Champions League final.
It seems Neymar and Lionel Messi have finally clicked as a partnership and, if last Saturday’s 6-0 drubbing of Granada is anything to go by, Barca will take some stopping.
Neymar scored a hat-trick in that game, while Messi's double saw him pass 400 career goals for club and country.
"My first year was a case of adaptation but I now feel better and able to perform at a higher level," said Neymar, who arrived at Barcelona from Santos in June 2013.
"We are combining more as a pair and I am very happy with the goals I am getting at the moment, which is down to the work of the team."
PSG will of course provide stiffer competition than Granada, but the French champions will do very well to keep the Catalans at bay at Parc des Princes.
Barcelona to win without conceding at 3.35
Neymar to score first at 6.00