Deportivo la Coruńa v Barcelona - Wednesday 19.00 GMT
Despite their surprising run of poor results the La Liga title is still in Barcelona's own hands. Level on points with Atletico and one point ahead of Real Madrid, it is now critical that Barca return to winning ways at The Riazor. The head to head advantage that Barca have over both chasing teams is the only reason Barca are in charge of their own destiny at the moment, but they cannot afford any more slip-ups.
This performance was not too bad against Valencia at the weekend but it was a performance that was filled with anxiety. That was reflected in a whole host of chances that Barca squandered and whilst I was co-commentating on the game I ticked off NINE "sitters" that were missed in total.
Once Valencia got the first goal of the game, totally against the run of play, that anxiety increased hugely, therefore Barca have to score the opening goal of the game on Wednesday against the La Liga draw specialists. Depor have drawn 17 games so far this season and have only won seven. They are nearly a decent team.
Barca's biggest opponents though in this game will be themselves! There isn't much of a case to make for Depor getting anything out of this game in normal circumstances but these are anything but normal circumstances!
The pace and skill of top scorer Lucas Perez is something that Barca have to keep an eye on without the suspended Gerard Pique, but it is fair to assume that Barca should be too strong if they can regain a little bit of calmness and composure in their finishing. Easier said than done.
They have the quality but can they hold their nerve?
I'm going to favour a Barca win, they will certainly feel better about themselves if they get the first goal and take one of the early chances they will undoubtedly create, and then they will be back on track again.
It's going to be a fascinating La Liga evening as Barca play first followed by Atletico and then we end up with Real Madrid against Villarreal. Are Barca going to stay top? Yes.
Messi to be first goalscorer and for Barca to win 3-0 for me.
Messi to score first & Barca to win 3-0 – 13.00
Athletic Bilbao - Atletico Madrid - Wednesday 19.45 GMT
On paper this is the toughest fixture left this season for Atletico Madrid. However if one team in La Liga are capable of dealing with the physical threat of Athletic Bilbao at San Mames it is Simeone's team.
Athletic will suffer in the absence of top scorer and talisman Aritz Aduriz who is out injured, but they will be boosted by the return of Ińaki Williams who is fit again to take his place. Atletico will have to watch out for former player Raul Garcia who will play just off of Williams but the absence of Aduriz is a game changer.
Don't expect anything other than a fully focused Atletico Madrid despite still being involved in the Champions League and they'll be at full strength in this game. Filipe Luis returns after missing the game against Granada at the weekend and Griezman and Torres will continue their improving partnership together up front.
This will be a battle but Atletico know that, and I'm expecting a narrow victory for Atletico Madrid with a 2-1 scoreline.
Atletico Madrid to win 2-1 – 9.50
Real Madrid - Villarreal - Wednesday 21.00 GMT
Will playing in the last game of the evening be an advantage to Real Madrid? Very possibly.
This kicks off after Barca have finished and with Atletico having played 15 minutes of the second half, and it could all be very dramatic.
Real know of course that a win is what they need whatever the other scorelines and once again this is another potentially tough fixture.
Europa League semi-final opponents for Liverpool and comfortably in 4th place in La Liga, Villarreal will look to bounce back after a surprising defeat at the weekend against relegation threatened Rayo Vallecano.
Under Marcelino they retain the traditional style of Villarreal teams of the past but their strength this season has been a solid defence. Statistically the 2nd best defence in the division is testimony to that, conceding only 28 goals.
They will be resolute, well drilled and look to start and end up with a clean sheet. Cedric Bakambu will lead the line and has the pace, power and skill to trouble Real on the counter attack.
Real's attack will be minus Gareth Bale who is out with a slight injury, and Zidane is taking no chances with the Welshman.
Pepe and Dani Carvajal are also not being risked by Zidane with slight niggles, so I'm wondering if Real still believe it is possible to win the league.
They should firmly believe it is possible but it is a balancing act by the Real Madrid coach in attempt to not hinder their chances against Manchester City in the Champions League semi-final.
I would imagine their will be decent viewing figures for this game as Liverpool and Manchester City fans will be tuning in doing their own scouting missions on their future opponents!
I have no doubt that this will be a tight game but I'm just going to go for a home victory in this one. We don't see many 1-0s at the Bernabeu but this is what I'm predicting in this game.
Real Madrid to win 1-0 – 13.00