Celta Vigo - Barcelona - 19.00 GMT
Both of these teams unbeaten so far this season. Barca have four wins from four and it's no surprise to see them top the league, but Celta have enjoyed a remarkable start also.
It's three wins and a draw for Celta and after an impressive victory at Sevilla on Sunday they will be going into this game in high spirits. Those high spirits will also be reinforced by their performances against Barcelona last season. A 1-0 home defeat and a 1-0 victory at the Nou Camp meant they were only one of four teams to beat them in last season's La Liga campaign.
In addtion Lionel Messi has suffered in the past v Celta, scoring only three times in eight appearances, averaging a goal every 232 minutes, and as we know by his standards and only his standards that is not particularly good!
Celta's star man is Nolito. He has four goals already this season and that is only bettered by Ronaldo in La Liga. However he has never scored against his former club Barca.
It was a full strength line up on Sunday for Eduardo Berrizo at Sevilla, but Luis Enrique was able to completely rest Luis Suarez, Andres Iniesta and Jordi Alba. All will be recalled for what will be a tough game.
I still think Barca will have too much for Celta, though, and will continue their winning start to this season.
A close game, but Barca edging it by a single goal.
Barcelona to win – 1.52
Barcelona to win 2-1 – 9.00
Athletic Bilbao - Real Madrid - 20.00 GMT
Will it be 3rd time lucky for Real Madrid at the new San Mames?
Since the move to the new stadium, Athletic have won and drawn at home to the Madrid giants, with the victory coming last season with a single goal from Aritz Aduriz - the "go to" man for Ernesto Valverde's team.
Athletic made six changes to their usual starting line up at the weekend suffering a 3-1 defeat at Villarreal. This coming on the back of two previous wins, one in La Liga v Getafe 3-1, and the same scoreline v Augsburg in the Europa League. All the players rested v Villarreal should be recalled for this midweek fixture.
Still yet to concede a goal this season, Real Madrid looked subdued in beating Granada 1-0 at the weekend and needed goalkeeper Keylor Navas to be at his best to play a huge part in picking up all three points.
There are one or two injury issues for Rafael Benitez's team, with no James Rodriguez or Gareth Bale, but Sergio Ramos will be left to the last minute to see if he is fit to play.
Karim Benzema scored the winner at the weekend and he is in good form at the moment, Athletic's Aduriz came of the bench to score a late consolation against Villarreal and Real's defence is going to be tested against him,Raul Garcia,Susaeta and Beńat, none of whom started the weekend fixture in an attempt to rest them before this game.
Athletic, backed by a super passionate crowd, will push Real all the way in a high octane fixture.
I'm going for a 2-2 draw.
Draw – 4.25
Correct Score: 2-2 – 16.00
Las Palmas - Sevilla - 21.00 GMT
This is a critical time for Sevilla, who start this round of fixtures winless and rock bottom of the division. Two draws and two defeats is a terrible start for Unai Emery's team whose focus appears to be on their Champions League campaign where they started off with an emphatic 3-0 win over Borussia Monchengladbach.
But they need to kickstart their La Liga campaign and have to do so immediately. Newly promoted Las Palmas away from home should be just the place to start that.
The hosts have shown plenty of endeavour but also remain without a win, and suffered a 1-0 home defeat against Rayo Vallecano at the weekend.
If anybody is going to score a goal for Las Palmas it will likely be Sergio Araujo, who scored 25 in last season's promotion campaign and has two of the three goals that Las Palmas have scored this season.
Fernando Llorente scored his first for his new club Sevilla at the weekend, but it wasn't enough to force a complete comeback v Celta from 2-0 down.
However, that will be a boost to him and I expect him to be prominent in a win for the visitors.
Sevilla to win – 2.20
Fernando Llorente to score at any time - 3.00