Arsenal perspective: James McNicholas, Gunnerblog
Arsenal are without first-choice centre-forward Olivier Giroud, who is suspended after being sent off against Fulham. Arsene Wenger must choose between Theo Walcott, Gervinho and Lukas Podolski to fill the central striking berth. Lukasz Fabianski also misses out with a cracked rib, meaning Wojciech Szczesny will continue in goal.
Arsenal are in the midst of their best run of the season. They are undefeated since the derby defeat against Tottenham Hotspur, notching up a string of wins that have taken them to third place in the Premier League. We know that four more wins will guarantee us Champions League football next season - although with United arriving in north London, that's easier said than done.
Although United beat Arsenal by just a single goal earlier this season, the gulf between the sides is a lot wider, as illustrated by the Premier League table. Arsenal have suffered from something of an inferiority complex ever since their 8-2 hammering at Old Trafford. This would be the perfect time to overcome that.
Lukas Podolski to score first at 7.75. The German is expected to earn a recall against United, and is one of the club's most lethal finishers. If he gets a chance against United, I expect him to bury it.
Over 3.5 goals at 2.85. United have nothing to lose. Arsenal can't defend. Robin van Persie will be desperate to score against his former club. All the signs point to goals.
The draw at 3.50. With the pre-match guard of honour set to turn in to a gauntlet of hate, emotions will be running high at the Emirates. Hopefully that spurs us on to earn a good point.
Score prediction: Arsenal 2-2 Manchester United
Man United perspective: Chudi Onwuazor, The Busby Way
With the title wrapped up Sir Alex Ferguson has confirmed that he will be rotating the team in order to let some of the fringe players get a some games. Specifically, he named Javier Hernandez, Tom Cleverley, Nani and Danny Welbeck. There are no new injuries, so expect to see some of these players start at the Emirates.
Whilst I haven't been impressed with United recently, the performance against Aston Villa, especially in the first half, was one of our best all season. We played with freedom and hammered Villa with some brilliant football. The win was our fourth in six games.
How the mighty have fallen! Arsenal's inability to compete with us on field has left their fans planning to do the Poznan as a show of defiance to Robin van Persie. But this will be of little consequence, especially as the Dutchman scored in United's 2-1 win in November.
Van Persie to score at 2.40. The striker has found his feet again, scoring a hat-trick against Villa as well as goals against West Ham and Stoke. He could clear the stands at the Emirates if he repeats the the trick on Sunday.
United clean sheet at 4.50. With no Giroud, Arsenal's goal threat is diminished. David De Gea has kept clean sheets in five of our last seven games, and I'm confident he can keep the Gooners at bay.
Under 2.5 goals at 2.05. This game may not be the goal fest some expect.
Score prediction: Arsenal 0-2 Man United (18.00)