After 750 minutes without a goal, Robin van Persie's relief at scoring against Stoke on Sunday was plain to see. He rushed over to embrace Sir Alex Ferguson on the touchline before exchanging high-fives with colleagues on the bench. He'll be the main threat once more for Man United as they travel to London to face a West Ham side that has edged ever further from the relegation scrap in recent weeks.
Andy Carroll's fine recent form should ensure he maintains his place up front for the Irons. He is likely to be supported by Matt Jarvis and Ricardo Vaz Te, with Joe Cole still out injured. Sam Allardyce may face a tough decision over his defence though: James Tomkins was forced off in the game against Southampton and may struggle to recover in time.
Sir Alex Ferguson is likely to make a couple of changes to the side that won at the Britannia. Rafael should return at right-back, which could mean Phil Jones gets shunted to centre-back or even midfield. Nani may earn a rare start on the flank, while Danny Welbeck and Tom Cleverley will also hope to be involved. Chicharito and Shinji Kagawa are the players most likely to make way.
West Ham have only lost one of their last five games, and have clawed their way into midtable as a result. Wins over Stoke and West Brom were followed by respectable draws at Anfield and St Marys as Sam Allardyce's side look to the season on a high note. United have been less impressive of late, struggling for form since their Champions League elimination at the hands of Real Madrid. Losses to Chelsea and Man City will have hurt Ferguson, even though the league title looks to heading to Old Trafford.
The Red Devils have won the last eight Premier League meetings between these sides, by an aggregate score of 21-3. That record looks ominous for the Londoners, but they can take heart from recent cup clashes: they held Man United at Upton Park earlier this season and picked up a memorable 4-0 win in the League Cup in 2010.
Robin van Persie got back on the goal trail on Sunday, tucking home a penalty he won himself in the second half. If you think the floodgates have reopened for the Dutchman, back him to score two or more at 5.50. West Ham's danger man is undoubtedly Carroll, who will pose the United defence problems with his height and power. He is a generous-looking 3.75 to net at Upton Park.
United haven't been firing on all cylinders of late, but still have plenty of quality. The win over Stoke will have boosted confidence, but they won't have things easy against this West Ham side. A narrow away win looks likely, with both teams to score a solid bet at 1.75.
Score prediction: West Ham 1-2 Man United (8.25)